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第一篇
< 綠茶多酚之成分-EGCG做為一種具潛力的抗癌藥物研究 >(-)-EGCG 是存在於兒茶素中含量最多並且具最高生化活性的物質，其作用是一種致癌蛋白?與癌細胞死亡之誘發劑。然而，(-)-EGCG 在一般生理狀況下是不穩定的並且不具良好之個體相容性。在目前的研究中，我們使用乳癌細胞以 pro-EGCG 作為藥物研究，發現 pro-EGCG 可以轉換成 (-)-EGCG 而且可以儲存在身上，並請會抑制 proteasome （可能引發癌症的一種存在人體內蛋白質）作用與細胞自然凋零的產生。研究 Pro-EGCG 做為一種有抗癌潛力的藥物，以 MDA-MB-231腫瘤誘發裸鼠得到癌症做實驗，並且以 Pro-EGCG 或 (-)-EGCG 治療裸鼠31天。結果發現 Pro-EGCG 在統計學上有意義的抑制乳癌。最後結果並顯示出 Pro-EGCG 可以增加生物活性、穩定性，並且抑制 proteasome 使具有抗癌功用，因此可以做為一種預防與治療癌症的天然藥物。 第二篇
< 多酚類與心血管疾病：於內皮細胞與血小板之作用 >流行病學的研究指出從食用大量的水果蔬菜所得到的多酚可降低罹患心血管疾病，雖然目前尚無明確理由可以完全解釋為何可以降低心血疾病，但是有一些研究數據說明了黃酮類（多酚的一種）可以改善人類血管內皮細胞的功能並且抑制血小板凝結（血小板凝結會導致心血管疾病）。血管內皮細胞維持血管恆定是重要的，若此內皮細胞失去功用則會導致動脈血管疾病。血小板的凝結是急性心血管症狀的主要原因，包括心肌梗塞和不穩定性心絞痛。基於上述理由，我們可以解釋為何黃酮類可以降低心血管疾病，並且可以部分說明黃酮類對與心血管疾病危險的效果。 第三篇
< 綠茶與肌膚 >植物萃取物已經廣泛的作為對創傷的醫治、抗老化以及疾病的治療，這些的萃取植物包括銀杏、紫錐花、人參、葡萄種子、綠茶、檸檬、薰衣草、迷迭香、金鐘柏、大豆、加州希蒙得木、蘆薈維拉、罌粟科植物、亞帕基印第安人羽毛和番木瓜等。他們具有一個共同的特性：均含有黃酮類化合物酚類結構。這些植物素是具高度活性的，可以中和自由基或一些連續的生物反應，例如高活性的氧氣和生物大分子。酚基植物素有益於人類健康，包括了多酚類的化合物，綠茶就被發現含有一種稱為兒茶素的多酚類。這篇使用綠茶多酚總結研究的結果作為疾病預防的介紹文章，包括自然癒合、皮膚抗老化以及疾病的致病機轉的研究。 第四篇
< 四氫薑黃素和綠茶多酚在公鼠（品種：C57BL/6）壽命之影響 >以四氫薑黃素（一種薑黃素代謝物）和綠茶多酚二種不同的抗氧化物餵養 C57BL/6 公鼠，並檢驗其生理狀況。100隻公鼠年紀為13個月，分成二群各50隻，一群以0.2%四氫薑黃素餵養，另一群則不添加四氫薑黃素於食物中，結果發現添加四氫薑黃素組的老鼠的壽命為882±154.6日，而未添加組則為797.6±151.2日(p<0.01)，壽命增加了11.7%。添加四氫薑黃素組壽命最長的五隻老鼠，其壽命比同組老鼠亦多了6.5%的壽命（ P < 0.01）。然而，在老鼠壽命為19個月的時候，在統計學並沒有發現這二組在平均壽命上有何區別。在老鼠的飲水裡添加茶多酚（濃度為80 mg/l ），其平均壽命為852.7±88.2日，比未添加組的平均壽命801 ±121.5日多了6.4%的壽命（ P < 0.05）。在體重方面，餵養四氫薑黃素的老鼠，前六個月其體重比另一組老鼠減少2~4%，並且在統計學上是有意義的。此後，這二組的體重均開始減少。雖然我們沒有預期四氫薑黃素可以減少老鼠的飲食攝取量，而讓老鼠減少體重。但是經由實驗結果可以得知，四氫薑黃素與茶多酚二個抗氧化劑可能有延長動物壽命的潛力。
－－－－－－－－－－－－以下為原文內容－－－－－－－－－－－－ 第一篇
The most abundant and biologically active green tea catechin, (-)-epigallocatechin-3-gallate or (-)-EGCG, has been shown to act as a proteasome inhibitor and tumor cell death inducer.However, (-)-EGCG is unstable under physiologic conditions and has poor bioavailability. Previously, in an attempt to increase the stability of (-)-EGCG, we introduced peracetate protections to its reactive hydroxyl groups and showed that this peracetate-protected (-)-EGCG [Pro-EGCG (1); formerly named compound 1] could be converted into (-)-EGCG under cell-free conditions. In the current study, we provide evidence that when cultured human breast cancer MDA-MB-231 cells were treated with Pro-EGCG (1), (-)-EGCG was not only converted but also accumulated, accompanied by enhanced levels of proteasome inhibition, growth suppression, and apoptosis induction, compared with cells treated with natural (-)-EGCG. To investigate the potential use of Pro-EGCG (1) as a novel prodrug that converts to a cellular proteasome inhibitor and anticancer agent in vivo, MDA-MB-231 tumors were induced in nude mice, followed by treatment with Pro-EGCG (1) or (-)-EGCG for 31 days. Results of this in vivo study showed a significant inhibition of breast tumor growth by Pro-EGCG (1), compared with (-)-EGCG, associated with increased proteasome inhibition and apoptosis induction in tumor tissues. In conclusion, we have shown that Pro-EGCG (1) increases the bioavailability, stability, and proteasome-inhibitory and anticancer activities of (-)-EGCG in human breast cancer cells and tumors, suggesting its potential use for cancer prevention and treatment. 第二篇
Epidemiologic studies suggest that higher polyphenol intake from fruits and vegetables is associated with decreased risk for cardiovascular disease. The mechanisms explaining this observation remain unclear. This review summarizes data suggesting that flavonoids improve endothelial function and inhibit platelet aggregation in humans. The vascular endothelium is a critical regulator of vascular homeostasis, and endothelial dysfunction contributes to the pathogenesis and clinical expression of coronary artery disease. Platelet aggregation is a central mechanism in the pathogenesis of acute coronary syndromes, including myocardial infarction and unstable angina. For these reasons, the observed effects of flavonoids on endothelial and platelet function might explain, in part, the observed beneficial effects of flavonoids on cardiovascular disease risk. 第三篇
Plant extracts have been widely used as topical applications for wound-healing, anti-aging, and disease treatments.Examples of these include ginkgo biloba, echinacea, ginseng, grape seed, green tea, lemon, lavender, rosemary, thuja, sarsaparilla, soy, prickly pear, sagebrush, jojoba, aloe vera, allantoin, feverwort, bloodroot, apache plume, and papaya. These plants share a common character: they all produce flavonoid compounds with phenolic structures. These phytochemicals are highly reactive with other compounds, such as reactive oxygen species and biologic macromolecules, to neutralize free radicals or initiate biological effects. A short list of phenolic phytochemicals with promising properties to benefit human health includes a group of polyphenol compounds, called catechins, found in green tea. This article summarizes the findings of studies using green tea polyphenols as chemopreventive, natural healing, and anti-aging agents for human skin, and discusses possible mechanisms of action. 第四篇
The effect of feeding of two different antioxidants, tetrahydrocurcumin (TC) and green tea polyphenols (PPs) on the survival of male C57BL/6 mice was examined. Mice that started to receive diets containing TC (0.2%) at the age of 13 months had significantly longer average life spans (days, mean +/- SD) than control mice (797.6 +/- 151.2 vs.882 +/- 154.6, both n = 50, controls vs. TC treated, plus 11.7%, P < 0.01). The 10% longest survival was also significantly greater in TC-treated mice (plus 6.5%, P < 0.01). In contrast, in mice that started to receive TC in their 19th month of life, no significant difference from the control mice was found for either the average life span or the 10% longest survival. In mice that received water containing PPs (80 mg/l), the average life span was also significantly longer than in the control mice (801 +/- 121.5 vs. 852.7 +/- 88.2, plus 6.4%, P < 0.05), although the 10% longest survival was not significantly different from that in the control mice (P > 0.05). The body weights of the TC (but not PP) fed mice, were slightly (2-4%) but significantly (P < 0.05) lower than the values for the corresponding ages in the control mice in the first six months of treatment. Thereafter, the difference in average body weight between the control and the TC-fed animals was totally lost. Although an additional contribution of an unintended slight decrease in food intake due to TC feeding (suspected due to the difference in body weight) is not excluded, we suggest that the feeding of nutritional antioxidants such as TC and PPs may have the potential to beneficially modify the life spans of animals.
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